Amidst the challenges confronting agriculture in Europe and Central Asia, this casebook unfolds the stories of 25 farmers and agripreneurs who have successfully embraced digital technologies. The accounts presented here reveal that, despite the effects of climate change, the consequences of the war in Ukraine and the enduring impact of COVID-19, opportunities for innovation and resilience can still be found. The case studies presented here, grouped into five distinct use cases, illustrate the transformative power of digitalization in agriculture, and serve as tangible examples of the successes and lessons learned on the path to sustainable development. By harnessing the power of digital technologies in agriculture, we can prepare ourselves for the digital transformation of agrifood systems, which are at the core of the 2030 Agenda for Sustainable Development, with effects on all 17 Sustainable Development Goals.