Highly Pathogenic Avian Influenza (HPAI) was first reported in Thailand in early 2004. The outbreaks caused severe mortality among affected flocks and substantial losses resulted from the subsequent control measures. Moreover, transmission of the disease from birds to people led to human fatalities in Thailand. In the years following the major outbreaks, Thailand has seen infrequent but repeated disease incidence. The sustained threat of a human pandemic requires the Thai government and other stakeholders to consider strategies for effectively managing HPAI risk in poultry populations.