The effect of three regimes against tick infestation of Amblyomma variegatum and dermatophilosis on cattle was evaluated in the coastal plains of Ghana. Animals in a kraal were treated every 15 days with amitraz highly concentrated in low-volume spray on preferential attachment sites of ticks. The animals of the other two kraals were treated with topical application of a ridge-based acaricide deltamethrin, for a month, and the other at strategic, based on the anticipated seasonal increases in the level of infestation by A. variegatum. Animals in the fourth kraal (control group) were treated by the herdsmen as traditional systems to prevent an excessive accumulation of ticks. The processing performed every 15 days reduced the level of infestation by A. variegatum and dermatophilosis frequency has fallen to a low level. The acaricide reduced the frequency of the disease in a similar manner.