This systematic review of peer-reviewed literature assesses the constrain and enabling factors to the uptake of medium- to long-term climate information in a wide range of sectoral investment and planning decisions. Common applications of climate information are shown to relate to the adaptation of environmental policy and planning, urban planning and infrastructure, as well as flood and coastal management. Analysis of identified literature highlights five categories of enablers to the uptake of medium- to long-term climate information in decision-making, the most frequent of which relates to greater collaboration and bridging between producers and users of climate information. Five categories of constraints are also identified, the largest comprising of scientific and technical limitations associated with available medium- to long-term climate information.