The Commission on Sustainable Agriculture and Climate Change has reviewed the scientific evidence to identify a pathway to achieving food security in the context of climate change. Food systems must shift to better meet human needs and, in the long term, balance with planetary resources. This will demand major interventions, at local to global scales, to transform current patterns of food production, distribution and consumption. Investment, innovation, and deliberate effort to empower the world’s most vulnerable populations will be required to construct a global food system that adapts to climate change and ensures food security while minimizing greenhouse gas emissions and sustaining our natural resource base. Greatly expanded investments in sustainable agriculture, including improving supporting infrastructure and restoring degraded ecosystems, are an essential component of long-term economic development. The sooner they are made, the greater the benefits will be.